One of the major obstacles in quantum information processing is to prevent a quantum bit from decoherence. One powerful approach to protect quantum coherence is dynamical decoupling. I will present some recent progress of diamond-based quantum information processing using dynamical decoupling. The other promising approach is to use topological quantum systems, which are intrinsically insensitive to local perturbations. I will discuss some ideas to create and probe topological quantum systems. Furthermore, I will propose a hybrid platform between topological and conventional quantum systems, which can combine the advantages from both.