Along with the development of computational resources computational fluid dynamics (CFD) has evolved in resolving the finest length scales and smallest time scales of the flow. Direct numerical simulation (DNS) resolves the finest flow scales known as Kolmogorov length scales which are responsible for the dissipation of the energy transferred from the large and intermediate length scales. However DNS simulations are computationally costly and demand very powerful resources which are not widely available to this day. Large eddy simulation (LES) is a more feasible tool to resolve the large flow scales and model the sub-grid scales using a Reynolds averaged modeling. High performance computing tools make it possible to perform high fidelity large eddy simulations which reasonably (almost twelve times the Kolmogorov length scale) resolve the flow structures.In the present study large eddy simulation is utilized to simulate interaction of a high speed compressible round air jet with a group of sprays injected from a six-hole nozzle injector into the shear layer of the air jet. Fuel sprays are injected with 10 and 15 MPa injection pressures in the jet cross flows of 125 and 215 m/s. Simulations are performed using 64 processors and 240 GB of memory. The focus of the study is on the spray atomization assisted by air jet cross-flow. Consequent processes of fuel/air mixing are also investigated by focusing on the role of vortical structures resolved using large eddy simulation.