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Accessible adult stem cells from mammalian skin – from basic biology to therapeutic utility

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We have previously isolated and characterized a multipotent precursor cell (termed SKPs for SKin-derived Precursors) from both rodent and human skin, and have shown that these stem cells share many characteristics with a multipotent stem cell that is found in the embryo termed a neural crest stem cell. Here I will discuss our current work with regard to the basic biology of these stem cells, with a focus on the “what, where and why”, and on their therapeutic potential with specific regard to the nervous system.